| Primary Identifier | MGI:99894 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 15387 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA binding activity. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome; positive regulation of transcription by RNA polymerase II; and regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in cytoplasmic stress granule. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; musculature; and sensory organ. Human ortholog(s) of this gene implicated in Raynaud disease. Orthologous to human HNRNPK (heterogeneous nuclear ribonucleoprotein K). PHENOTYPE: Male mice homozygous for a conditional allele activated in male germ cells exhibit small testes, reduced body size, meiotic arrest at prophase, increased male germ cell apoptosis, and infertility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
