Primary Identifier | MGI:1923501 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 76251 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein kinase binding activity. Predicted to be involved in cellular response to reactive oxygen species and interstrand cross-link repair. Predicted to be located in mitochondrion and nucleus. Predicted to be part of protein-containing complex. Predicted to colocalize with centrosome. Orthologous to human ERCC6L2 (ERCC excision repair 6 like 2). PHENOTYPE: Homozygous knockout affects DNA damage repair and results in reduced class switch recombination in B cells, reduced T cell numbers and reduced IgA and IgG serum levels. [provided by MGI curators] |