Primary Identifier | MGI:2441808 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 218294 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including positive regulation of ubiquitin protein ligase activity; protein dephosphorylation; and regulation of cell cycle process. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm; nucleolus; and spindle. Is expressed in embryo. Orthologous to several human genes including CDC14B (cell division cycle 14B). PHENOTYPE: Mice homozygous for a knock-out allele exhibit premature aging, including premature cataracts and kyphosis; reduced fertility, particularly in female mice; and impaired contextual conditioning. [provided by MGI curators] |