| Primary Identifier | MGI:2145349 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 105278 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including chordate embryonic development; embryonic organ development; and negative regulation of smoothened signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in bronchiole; thymus primordium; and trachea. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human CDK20 (cyclin dependent kinase 20). PHENOTYPE: Mice homozygous for a null allele display exencephaly, open neural tubes, cleft palate, absence of the floor plate, achondroplasia of the radius and ulna, and abnormal cilia. [provided by MGI curators] |