| Primary Identifier | MGI:94862 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 13162 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables dopamine binding activity; dopamine:sodium symporter activity; and neurotransmitter transmembrane transporter activity. Involved in dopamine uptake; hyaloid vascular plexus regression; and neurotransmitter uptake. Acts upstream of or within several processes, including dopamine metabolic process; lactation; and prepulse inhibition. Located in axon terminus and cell surface. Is expressed in genitourinary system; nervous system; spleen; and submandibular gland. Used to study Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and schizophrenia. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; classic dopamine transporter deficiency syndrome; mild cognitive impairment; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). PHENOTYPE: Homozygotes for targeted null mutations exhibit dwarfism, hyperactivity (especially in a novel environment), 5-fold higher extracellular dopamine levels, impaired spatial cognitive function, anterior pituitary hypoplasia, and failure to lactate. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
