| Primary Identifier | MGI:99835 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 18420 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within nervous system development and positive regulation of neuroblast proliferation. Predicted to be located in fibrillar center and nuclear body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human OTP (orthopedia homeobox). PHENOTYPE: Homozygous mutation of this gene results in impaired development of neuroendocrine cell lineages in the hypothalamus and of diencephalic dopaminergic neurons. Mice homozygous for a certain point mutation die around birth. Heterozygosity causes obesity with increased lean and body fat mass, hyperlipidemia, hyperinsulinemia, insulin resistance and impaired glucose tolerance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
