| Primary Identifier | MGI:2449975 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 544963 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including Arp2/3 complex binding activity; GTPase activator activity; and calmodulin binding activity. Predicted to be involved in actin filament organization; regulation of actin cytoskeleton organization; and thrombin-activated receptor signaling pathway. Located in microvillus. Is expressed in several structures, including alimentary system; axial skeleton; central nervous system; genitourinary system; and liver. Used to study hepatocellular carcinoma. Orthologous to human IQGAP2 (IQ motif containing GTPase activating protein 2). PHENOTYPE: Mice homozygous for a null mutation display reduced survival with increased incidence of hepatocellular carcinomas, increased hepatocyte apoptosis, and hepatocyte mitochondrial abnormalities. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
