Primary Identifier | MGI:1298208 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 14064 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables proteinase-activated receptor activity and receptor ligand activity. Involved in G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; and positive regulation of insulin secretion. Located in apical plasma membrane. Is expressed in several structures, including central nervous system; liver; retina; skin; and spleen. Orthologous to human F2RL2 (coagulation factor II thrombin receptor like 2). PHENOTYPE: Homozygous mutation of this gene results in prolonged bleeding times, delayed and reduced thrombin responses in platelets, and protection against thrombosis. [provided by MGI curators] |