Primary Identifier | MGI:1349767 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 27015 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables molecular adaptor activity. Acts upstream of or within DNA repair. Located in nucleus. Is expressed in several structures, including adrenal gland; eye; gonad; lung; and stomach. Orthologous to human POLK (DNA polymerase kappa). PHENOTYPE: Homozygous mutation of this gene that results in a truncated transcript results in a higher rate of spontaneous germline expanded simple tandem repeat mutations. Homozyogus null mice exhibit normal immunoglobulin gene somatic hypermutation. [provided by MGI curators] |