Primary Identifier | MGI:1347463 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 15229 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including kidney development; luteinizing hormone secretion; and regulation of gene expression. Acts upstream of or within axon guidance and branching involved in ureteric bud morphogenesis. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; metanephros; nervous system; and sensory organ. Orthologous to human FOXD1 (forkhead box D1). PHENOTYPE: Mice homozygous for this targeted mutation die within 24 hours after birth with severe defects in nephrogenesis, and abnormal development of the renal collecting system. [provided by MGI curators] |