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Protein Coding Gene : Adamts6 ADAM metallopeptidase with thrombospondin type 1 motif 6
Primary Identifier  MGI:1347348 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  108154
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable metalloendopeptidase activity. Acts upstream of or within circulatory system development and kidney development. Predicted to be active in extracellular matrix. Is expressed in embryo. Orthologous to human ADAMTS6 (ADAM metallopeptidase with thrombospondin type 1 motif 6).
PHENOTYPE: Mice homozygous for induced mutations exhibit cardiovascular defects including double outlet right ventricle, ventricular septal defects and biventricular hypertrophy, and hydrops, thymus hypoplasia short snout and cleft palate. [provided by MGI curators]
  • synonyms:
  • Adamts6,
  • Mutant line 2029,
  • Mutant line 2228,
  • MGI:5476177,
  • b2b2029Clo,
  • Mutant line 1879.1,
  • MGI:5487285,
  • ADAM-TS6,
  • RIKEN cDNA A930019D11 gene,
  • MGI:5547739,
  • b2b2187.1Clo,
  • b2b2182Clo,
  • ADAM metallopeptidase with thrombospondin type 1 motif 6,
  • MGI:5491169,
  • Mutant line 2182,
  • MGI:2444985,
  • A930019D11Rik,
  • Mutant line 2187.1,
  • b2b2228Clo,
  • MGI:5491167,
  • b2b1879.1Clo
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