| Primary Identifier | MGI:1914513 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 67263 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable zinc ion binding activity. Involved in striatal medium spiny neuron differentiation. Acts upstream of or within neuron projection morphogenesis and regulation of neuron migration. Located in stereocilium. Is expressed in several structures, including forebrain; hair outer root sheath; jaw; midbrain mantle layer; and sensory organ. Human ortholog(s) of this gene implicated in acromelic frontonasal dysostosis. Orthologous to human ZSWIM6 (zinc finger SWIM-type containing 6). PHENOTYPE: Mice homozygous for a knock-out allele exhibit partial postnatal lethality, decreased striatal volume, abnormal medium spiny neuron morphology, and altered motor control including hyperactivity, impaired rotarod performance, repetitive movements, and behavioral hyperresponsiveness to amphetamine. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
