| Primary Identifier | MGI:1918940 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 71690 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable hepatocyte growth factor receptor binding activity and integrin binding activity. Predicted to be involved in positive regulation of cell population proliferation; positive regulation of hepatocyte growth factor receptor signaling pathway; and sprouting angiogenesis. Predicted to be located in extracellular region. Is expressed in several structures, including lower jaw; metanephros; neural retina; pineal primordium; and spleen. Orthologous to human ESM1 (endothelial cell specific molecule 1). PHENOTYPE: Homozygous null mice show delayed vascular outgrowth and reduced filopodia extension in the retina, reduced leukocyte transmigration, reduced VEGF-induced vascular permeability, and reduced cerebral edema due to ischemic stroke-induced vascular permeability. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
