| Primary Identifier | MGI:1277947 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 14198 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including adenosine 5'-monophosphoramidase activity; adenylylsulfate-ammonia adenylyltransferase activity; and hydrolase activity, acting on acid anhydrides. Acts upstream of or within DNA replication. Located in cytoplasm. Is expressed in brain; genitourinary system; liver; mammary gland; and spleen. Used to study Muir-Torre syndrome. Human ortholog(s) of this gene implicated in carcinoma (multiple); invasive ductal carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human FHIT (fragile histidine triad diadenosine triphosphatase). PHENOTYPE: Both homozygotes and heterozygotes for a targeted null mutation exhibit a similarly increased incidence of both spontaneous and nitrosomethylbenzalamine-induced tumors. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
