Primary Identifier | MGI:96553 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 16188 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable interleukin-3 receptor activity. Acts upstream of or within interleukin-3-mediated signaling pathway. Predicted to be located in endomembrane system and plasma membrane. Is expressed in several structures, including bone marrow; cardiovascular system mesenchyme; dorsal aorta; early conceptus; and umbilical or vitelline vessel. Orthologous to human IL3RA (interleukin 3 receptor subunit alpha). PHENOTYPE: A number of distantly related inbred mouse strains carrying an identical spontaneous deletion at the branch point in intron 7 exhibit a reduced capacity of bone marrow cells to form colonies in response to interleukin-3 in CFU-GM assays. [provided by MGI curators] |