| Primary Identifier | MGI:99433 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 11843 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including GTP binding activity; NAD+-protein-arginine ADP-ribosyltransferase activity; and epidermal growth factor receptor binding activity. Involved in regulation of postsynapse organization. Acts upstream of or within several processes, including apical protein localization; dendritic spine development; and establishment or maintenance of epithelial cell apical/basal polarity. Located in Golgi apparatus and plasma membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; extraembryonic component; nervous system; nose; and skeleton. Orthologous to human ARF4 (ARF GTPase 4). PHENOTYPE: Mice homozygous for a gene trap allele exhibit embryonic lethality. Mice heterozygous for the gene trap allele exhibit failure to increase exploration of an object in a novel context, reduced spine density and reduced mESPC amplitudes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
