Primary Identifier | MGI:105992 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 21881 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables transketolase activity. Involved in pentose-phosphate shunt, non-oxidative branch and xylulose 5-phosphate biosynthetic process. Acts upstream of or within regulation of growth. Located in myelin sheath. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TKT (transketolase). PHENOTYPE: Homozygotes for a targeted null mutation die at or before the morula stage. Heterozygotes show reduced growth, decreased fat accumulation, microphthalmia, and reduced female fertility. [provided by MGI curators] |