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Protein Coding Gene : Pbrm1 polybromo 1
Primary Identifier  MGI:1923998 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  66923
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables chromatin binding activity. Acts upstream of or within blastocyst formation; heart development; and placenta development. Located in kinetochore. Is expressed in 1st branchial arch; central nervous system; early conceptus; genitourinary system; and heart. Human ortholog(s) of this gene implicated in extrahepatic bile duct adenocarcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and renal cell carcinoma. Orthologous to human PBRM1 (polybromo 1).
PHENOTYPE: Homozygous null mice display embryonic lethality with hypoplastic cardiac ventricular chambers and malformation of the placenta. [provided by MGI curators]
  • synonyms:
  • 2610016F04Rik,
  • MGI:2145667,
  • BAF180,
  • expressed sequence AI507524,
  • AI507524,
  • MGI:1914173,
  • 2310032M22Rik,
  • Pbrm1,
  • Pb1,
  • polybromo 1,
  • RIKEN cDNA 2610016F04 gene
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