| Primary Identifier | MGI:107721 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 110084 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Acts upstream of or within epithelial cilium movement involved in extracellular fluid movement and flagellated sperm motility. Located in sperm flagellum. Is expressed in cerebellum; choroid plexus; and lateral ventricle choroid plexus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 37 and spermatogenic failure 18. Orthologous to human DNAH1 (dynein axonemal heavy chain 1). PHENOTYPE: Homozygous null mice show male sterility, asthenospermia, and reduced beat frequency in tracheal cilia. Males homozygous for an ENU-induced mutation are sterile with abnormal sperm clumping behavior, asthenospermia, low in vitro fertilization rate, and impaired sperm penetration of zona pellucida. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
