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Protein Coding Gene : Dph3 diphthamine biosynthesis 3
Primary Identifier  MGI:1922658 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  105638
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable electron transfer activity; ferrous iron binding activity; and iron chaperone activity. Involved in protein histidyl modification to diphthamide. Part of protein-containing complex. Is active in cytosol. Orthologous to several human genes including DPH3 (diphthamide biosynthesis 3).
PHENOTYPE: Homozygous null mice display embryonic lethality during organogenesis, failure of chorioallantoic fusion, impaired placental development, and embryonic growth retardation. [provided by MGI curators]
  • synonyms:
  • diphthamine biosynthesis 3,
  • 2610018L09Rik,
  • DESR1,
  • DELGIP1,
  • zinc finger, CSL domain containing 2,
  • Dph3,
  • expressed sequence AV083614,
  • KTI11,
  • RIKEN cDNA 5730511P15 gene,
  • MGI:1917878,
  • AV083614,
  • expressed sequence AL022916,
  • MGI:2145777,
  • Zcsl2,
  • AL022916,
  • RIKEN cDNA 2610018L09 gene,
  • MGI:2145713,
  • 5730511P15Rik
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