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Protein Coding Gene : Ncoa4 nuclear receptor coactivator 4
Primary Identifier  MGI:1350932 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  27057
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Acts upstream of or within intracellular iron ion homeostasis. Located in mitochondrion. Is expressed in several structures, including heart; lung; metanephros; reproductive system; and spleen. Orthologous to human NCOA4 (nuclear receptor coactivator 4).
PHENOTYPE: Mouse embryonic fibroblasts isolated from homozygous null mice exhibit abnormal DNA replication, decreased fibroblast proliferation, and early cellular replicative senescence. [provided by MGI curators]
  • synonyms:
  • 4432406M01Rik,
  • AI227008,
  • expressed sequence AI227008,
  • RIKEN cDNA 4432406M01 gene,
  • 1110034E15Rik,
  • MGI:1913942,
  • MGI:1915907,
  • RIKEN cDNA 1110034E15 gene,
  • Ncoa4,
  • nuclear receptor coactivator 4,
  • MGI:2145605
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