| Primary Identifier | MGI:88017 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 11720 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including adenyl ribonucleotide binding activity; magnesium ion binding activity; and methionine adenosyltransferase activity. Predicted to be involved in S-adenosylmethionine biosynthetic process; methionine catabolic process; and protein homotetramerization. Predicted to be located in nuclear matrix. Predicted to be part of methionine adenosyltransferase complex. Predicted to be active in cytosol. Is expressed in several structures, including foregut-midgut junction; liver; nervous system; respiratory system; and secondary oocyte. Human ortholog(s) of this gene implicated in hypermethioninemia. Orthologous to human MAT1A (methionine adenosyltransferase 1A). PHENOTYPE: Mice homozygous for disruptions in this gene have significantly elevated levels of methionine in the circulation and develop liver steatosis with age. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
