| Primary Identifier | MGI:1354385 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 50527 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein-disulfide reductase activity. Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress and release of sequestered calcium ion into cytosol. Acts upstream of or within several processes, including brown fat cell differentiation; carboxylic acid metabolic process; and cell redox homeostasis. Is active in endoplasmic reticulum. Is expressed in several structures, including adipose tissue; bone; liver; lung; and spleen. Orthologous to human ERO1A (endoplasmic reticulum oxidoreductase 1 alpha). PHENOTYPE: Mice homozygous for a gene trapped allele exhibit decreased apoptosis and calcium release in macrophages exposed to endoplasmic reticulum stress. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
