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Protein Coding Gene : Socs4 suppressor of cytokine signaling 4
Primary Identifier  MGI:1914546 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  67296
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to be involved in cytokine-mediated signaling pathway; negative regulation of epidermal growth factor-activated receptor activity; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Is expressed in ganglia; sensory organ; thymus primordium; and ventricular layer. Orthologous to human SOCS4 (suppressor of cytokine signaling 4).
PHENOTYPE: Homozygosity for a knockout allele leads to increased susceptibility to influenza-virus-induced morbidity and mortality. [provided by MGI curators]
  • synonyms:
  • MGI:2145722,
  • suppressor of cytokine signaling 4,
  • 3110032M18Rik,
  • Socs4,
  • MGI:2145633,
  • MGI:2145724,
  • RIKEN cDNA 3110032M18 gene,
  • Socs7,
  • expressed sequence AU015727,
  • A730004F22Rik,
  • suppressor of cytokine signaling 7,
  • AU015727,
  • AU015859,
  • expressed sequence AI427843,
  • RIKEN cDNA A730004F22 gene,
  • expressed sequence AU015859,
  • AI427843
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