Primary Identifier | MGI:2684326 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 214922 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables zinc ion transmembrane transporter activity. Involved in keratinocyte differentiation and zinc ion transmembrane transport. Acts upstream of or within zinc ion transport. Located in plasma membrane. Is expressed in several structures, including genitourinary system; gut; liver; spleen; and yolk sac. Orthologous to human SLC39A2 (solute carrier family 39 member 2). PHENOTYPE: Homozygotes for a null allele are overtly normal when fed a zinc-replete diet but show increased sensitivity to the effects of maternal dietary zinc deficiency during pregnancy. Resulting embryos are often growth retarded with craniofacial and limb defects, and show altered iron and calcium levels. [provided by MGI curators] |