| Primary Identifier | MGI:1352498 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 29811 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of vascular associated smooth muscle cell proliferation; and regulation of cytokine production. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculoskeletal system; and sensory organ. Orthologous to human NDRG2 (NDRG family member 2). PHENOTYPE: Mice homozygous for a null allele develop various types of tumors, including T-cell lymphomas, and have a shorter lifespan. Homozygotes for a second null allele show vertebral transformations. Homozygotes for a third null allele show reduced astrogliosis and inflammatory response after brain injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
