| Primary Identifier | MGI:1915022 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 67772 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including chromatin binding activity; histone binding activity; and p53 binding activity. Involved in negative regulation of DNA-templated transcription and negative regulation of apoptotic process. Acts upstream of or within several processes, including negative regulation of fibroblast apoptotic process; prepulse inhibition; and social behavior. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; nervous system; and sensory organ. Used to study autism spectrum disorder. Orthologous to human CHD8 (chromodomain helicase DNA binding protein 8). PHENOTYPE: Homozygous null embryos are growth retarded starting at E5.5 and exhibit developmental arrest at E6.5. Mutants develop into an egg cylinder but do not form a primitive streak or mesoderm and exhibit increased apoptosis at E7.5. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
