Primary Identifier | MGI:1261794 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 219072 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable microtubule minus-end binding activity. Predicted to be involved in centrosome cycle and spindle assembly. Predicted to be located in centrosome and mitotic spindle microtubule. Predicted to be part of HAUS complex. Is expressed in cartilage; musculoskeletal system; and sensory organ. Orthologous to human HAUS4 (HAUS augmin like complex subunit 4). PHENOTYPE: Mice homozygous for a knock-out allele show embryonic growth retardation and complete embryonic lethality. In vitro, embryos hatch from the zona pellucida but form irregular outgrowths with small/no ICM colony after 3 days in culture. [provided by MGI curators] |