| Primary Identifier | MGI:1341886 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 16475 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including actin filament binding activity; alpha-catenin binding activity; and transcription corepressor activity. Involved in positive regulation of canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; focal adhesion assembly; and regulation of kinase activity. Located in several cellular components, including cytosol; focal adhesion; and lamellipodium. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; jaw; sensory organ; and telencephalon. Orthologous to human AJUBA (ajuba LIM protein). PHENOTYPE: Mice homozygous for one null allele are viable and reach adulthood without any obvious phenotypes; however, mouse embryonic fibroblasts exhibit impaired cell migration and abnormal lamellipodia production in vitro. Mice homozygous for a different null allele exhibit complete embryonic lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
