| Primary Identifier | MGI:108052 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 12050 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable channel activity; identical protein binding activity; and protein domain specific binding activity. Acts upstream of or within Sertoli cell proliferation and extrinsic apoptotic signaling pathway in absence of ligand. Located in cytosol and mitochondrial membrane. Is expressed in several structures, including brain; early conceptus; eye; female reproductive system; and intestine. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to several human genes including BCL2L2 (BCL2 like 2). PHENOTYPE: Homozygous null mutants are male sterile with progressive loss of germ cells, Sertoli cells and Leydig cells beginning at puberty. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
