| Primary Identifier | MGI:1920431 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 73181 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; long-term memory; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including circulatory system development; intracellular signal transduction; and positive regulation of apoptotic process. Located in cytosol and nucleus. Part of transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; heart; and maxillary process. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human NFATC4 (nuclear factor of activated T cells 4). PHENOTYPE: Mice homozygous for a knock-out allele are viable and overtly normal and exhibit normal embryonic heart morphology as well as normal pathophysiologic cardiac hypertrophy in response to angiotensin II infusion or aortic banding. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
