| Primary Identifier | MGI:96941 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 17228 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable peptide binding activity and serine-type endopeptidase activity. Predicted to be involved in several processes, including basement membrane disassembly; cytokine precursor processing; and positive regulation of angiogenesis. Predicted to be located in several cellular components, including cytoplasmic ribonucleoprotein granule; cytosol; and secretory granule. Predicted to be active in extracellular space. Is expressed in several structures, including lip; male external genitalia; skin; tongue; and yolk sac. Human ortholog(s) of this gene implicated in asthma; atopic dermatitis; hypertrophic cardiomyopathy; and sarcoidosis. Orthologous to human CMA1 (chymase 1). PHENOTYPE: Mice homozygous for a knock-out allele display a reduction in mast cell-mediated ischemia reperfusion injury of skeletal muscle. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
