| Primary Identifier | MGI:109267 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 14939 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables serine-type endopeptidase activity. Involved in defense response to bacterium; granzyme-mediated programmed cell death signaling pathway; and protein maturation. Acts upstream of or within T cell mediated cytotoxicity. Located in cytolytic granule and extracellular space. Is active in cytoplasm. Is expressed in extraembryonic component; labyrinthine zone; placenta; and thymus primordium. Orthologous to human GZMB (granzyme B). PHENOTYPE: Homozygotes for a null allele show impaired CTL and NK cell cytolysis, and enhanced clearance of allogeneic and syngeneic tumor cells. Homozygotes for another null allele have defective CTL cytolysis and show impaired clearance of allogeneic tumor cells only if the selection cassette is retained. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
