| Primary Identifier | MGI:1354386 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 50523 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein serine/threonine kinase activity. Involved in G1/S transition of mitotic cell cycle; negative regulation of protein localization to nucleus; and regulation of signal transduction. Acts upstream of or within several processes, including hippo signaling; inner cell mass cell differentiation; and negative regulation of canonical Wnt signaling pathway. Located in spindle pole. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human LATS2 (large tumor suppressor kinase 2). PHENOTYPE: Homozygous null mice display embryonic lethality with decreased cell proliferation, chromosomal instability, atrial hyperplasia, ventricular hypoplasia, delayed embryonic development, an irregular kinked neural tube, and hemorrhages. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
