Primary Identifier | MGI:2685139 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 239122 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable histone H3K9 methyltransferase activity. Predicted to be involved in several processes, including heterochromatin organization; left/right pattern formation; and negative regulation of macromolecule biosynthetic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including gonad; nervous system; and nose. Orthologous to human SETDB2 (SET domain bifurcated histone lysine methyltransferase 2). PHENOTYPE: Mice homozygous for a hypomorphic allele exhibit altered response to infection and improved patology following superinfection of influenza virus-infected mice with S. pneumonia. [provided by MGI curators] |