Primary Identifier | MGI:1914081 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 69008 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in intracellular signal transduction. Is expressed in several structures, including alimentary system; cardiovascular system; eye; genitourinary system; and nervous system. Orthologous to human CAB39L (calcium binding protein 39 like). PHENOTYPE: Homozygous null mice show dysregulated basal-to-luminal urothelial differentiation, with expansion of the basal undifferentiated layer of the bladder urothelium, and show increased susceptibility to tobacco-related carcinogen BBN-induced basal bladder cancer. [provided by MGI curators] |