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Protein Coding Gene : Prss55 serine protease 55
Primary Identifier  MGI:1918287 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  71037
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable serine-type endopeptidase activity. Involved in binding activity of sperm to zona pellucida and flagellated sperm motility. Located in acrosomal vesicle and plasma membrane. Orthologous to human PRSS55 (serine protease 55).
PHENOTYPE: Different knockout strategies result in inconsistent male reproduction phenotypes ranging from normal spermatogenesis and fertility to severe subfertility with astheno/teratozoospermia and low sperm ATP content to infertility with impaired sperm migration and sperm-egg recognition/binding defects. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 4933401F05 gene,
  • Prss55,
  • 4933401F05Rik,
  • serine protease 55
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2 Involved In Mutations

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