Primary Identifier | MGI:1860765 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 54616 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein-hormone receptor activity. Involved in several processes, including negative regulation of cytokine production involved in inflammatory response; negative regulation of inflammatory response to wounding; and negative regulation of keratinocyte differentiation. Is active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; heart; metanephros; and sensory organ. Orthologous to human EXTL3 (exostosin like glycosyltransferase 3). PHENOTYPE: Mice homozygous for a null mutation display embryonic lethality during organogenesis and lack heparan sulfate derived disaccharides. [provided by MGI curators] |