| Primary Identifier | MGI:108476 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 14365 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables Wnt receptor activity. Involved in several processes, including axon guidance; positive regulation of neuroblast proliferation; and sympathetic ganglion development. Acts upstream of or within several processes, including inner ear morphogenesis; nervous system development; and post-anal tail morphogenesis. Located in several cellular components, including apical plasma membrane; filopodium tip; and lateral plasma membrane. Is active in glutamatergic synapse and presynaptic active zone membrane. Colocalizes with presynaptic active zone. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome and schizophrenia. Orthologous to human FZD3 (frizzled class receptor 3). PHENOTYPE: Mice homozygous for disruption of this gene die within 30 minutes of birth. Breathing is irregular. Brain development is abnormal with occasion falure of the cephalic neural tube to close. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
