| Primary Identifier | MGI:105308 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 18155 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables receptor ligand activity. Involved in neuron-neuron synaptic transmission and sensory perception of pain. Is active in synaptic membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in neonatal abstinence syndrome. Orthologous to human PNOC (prepronociceptin). PHENOTYPE: Mice homozygous for a knock-out allele fail to exhibit prostaglandin E2-induced allodynia. Mice homozygous for a different knock-out allele display increased naloxone-precipitated jumping in response to morphine treatment. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
