| Primary Identifier | MGI:1340894 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 11495 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable metalloendopeptidase activity. Acts upstream of or within several processes, including adult behavior; positive regulation of gene expression; and visual learning. Part of protein-containing complex. Is active in cell surface. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human ADAM2 (ADAM metallopeptidase domain 2). PHENOTYPE: Mice homozygous for targeted mutations that inactivate the gene are viable, females are fertile, but males have severely reduced fertility. Mutant male sperm are defective in sperm-egg membrane adhesion, sperm-egg fusion, migration from the uterus to theoviduct, and binding to the egg zona pellucida. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
