| Primary Identifier | MGI:1914104 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 66854 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within negative regulation of cell population proliferation and positive regulation of myeloid cell apoptotic process. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; lung; and sensory organ. Orthologous to human TRIM35 (tripartite motif containing 35). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased serum interferon-beta levels in response to vesicular stomatitis virus infection and show increased susceptibility to influenza A virus infection. [provided by MGI curators] |