| Primary Identifier | MGI:95789 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 14714 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable gonadotropin hormone-releasing hormone activity and gonadotropin-releasing hormone receptor binding activity. Acts upstream of or within several processes, including negative regulation of neuron migration; regulation of ovarian follicle development; and response to ethanol. Located in extracellular space. Is expressed in several structures, including alimentary system; nervous system; olfactory system; and testis. Used to study hypogonadotropic hypogonadism 12 with or without anosmia. Human ortholog(s) of this gene implicated in breast cancer; hypogonadotropic hypogonadism 12 with or without anosmia; and periodontitis. Orthologous to human GNRH1 (gonadotropin releasing hormone 1). PHENOTYPE: Homozygous mutants are characterized by the failure of the sex organs to develop postnatally, resulting in sterility in both males and females. Deficiency in hypothalamic GnRH results in deficiencies of LH, FSH and gonadal steroids. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
