| Primary Identifier | MGI:97314 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 18040 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable signaling receptor binding activity and toxic substance binding activity. Predicted to be a structural constituent of cytoskeleton. Acts upstream of or within axo-dendritic transport; cytoskeleton organization; and regulation of axon diameter. Located in several cellular components, including neurofilament; neuromuscular junction; and postsynaptic density. Is active in postsynaptic intermediate filament cytoskeleton and presynaptic intermediate filament cytoskeleton. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ; and urogenital ridge. Human ortholog(s) of this gene implicated in Alzheimer's disease and human immunodeficiency virus infectious disease. Orthologous to human NEFM (neurofilament medium chain). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced axon diameter. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
