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Protein Coding Gene : Adam28 a disintegrin and metallopeptidase domain 28
Primary Identifier  MGI:105988 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  13522
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable immunoglobulin receptor binding activity and metalloendopeptidase activity. Predicted to be involved in proteolysis. Located in plasma membrane. Is expressed in foregut; nasal cavity epithelium; respiratory system; and thymus. Human ortholog(s) of this gene implicated in breast cancer; estrogen-receptor positive breast cancer; invasive ductal carcinoma; lung adenocarcinoma; and lung non-small cell carcinoma. Orthologous to human ADAM28 (ADAM metallopeptidase domain 28).
PHENOTYPE: Homozygous knockout increases metastatic pulmonary colonization after injection with tumor cells as a result of reduced pulmonary CD8+ T cell invasion. [provided by MGI curators]
  • synonyms:
  • Adam28,
  • disintegrin 1,
  • RIKEN cDNA C130072N01 gene,
  • C130072N01Rik,
  • MGD-MRK-33668,
  • MDC-L,
  • Dtgn1,
  • MGI:2442612,
  • MGI:2443863,
  • RIKEN cDNA D430033C21 gene,
  • D430033C21Rik,
  • a disintegrin and metallopeptidase domain 28
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