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Protein Coding Gene : Sorbs3 sorbin and SH3 domain containing 3
Primary Identifier  MGI:700013 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  20410
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable vinculin binding activity. Acts upstream of or within cell-substrate adhesion; negative regulation of transcription by RNA polymerase II; and positive regulation of MAPK cascade. Located in cytoplasm; focal adhesion; and nucleus. Is expressed in several structures, including eye; gonad; heart; hindbrain; and long bone epiphysis. Orthologous to human SORBS3 (sorbin and SH3 domain containing 3).
PHENOTYPE: Homozygous mutants are generally normal, viable, and fertile, except showing delayed wound healing in response to full-thickness skin injury in vivo. [provided by MGI curators]
  • synonyms:
  • Sorbs3,
  • SH3P3,
  • vinexin beta,
  • vinexin alpha,
  • Sh3d4,
  • sorbin and SH3 domain containing 3,
  • SH3 domain protein 4
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

2 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For





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