| Primary Identifier | MGI:109521 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 15558 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein tyrosine kinase activator activity. Acts upstream of or within positive regulation of fat cell differentiation; positive regulation of phosphate metabolic process; and protein localization to cytoskeleton. Predicted to be located in several cellular components, including cell body fiber; dendritic shaft; and neurofilament. Predicted to be part of G protein-coupled serotonin receptor complex. Predicted to be active in dendrite; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; embryo mesenchyme; and heart. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcoholic psychosis; cocaine dependence; nicotine dependence; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A). PHENOTYPE: Mice homozygous for a knock-out allele show altered anxiety-related responses and increased vertical activity. Mice homozygous for a different knock-out allele exhibit abnormal enterocyte, Paneth cell and smooth muscle morphology. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
