| Primary Identifier | MGI:2684060 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 219181 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein kinase A regulatory subunit binding activity. Acts upstream of or within cortical actin cytoskeleton organization; protein localization to endosome; and renal water homeostasis. Predicted to be located in several cellular components, including cytosol; nucleolus; and peroxisome. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; eye; genitourinary system; immune system; and nervous system. Orthologous to human AKAP11 (A-kinase anchoring protein 11). PHENOTYPE: Mice homozygous for a knock-out allele show a reduction in body size, body length and tibia length, hypoactivity, slow movement and increased anxiety-related responses, and exhibit actin barrier defects in kidney collecting duct cells and increased urine osmolality in response to overhydration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
