Primary Identifier | MGI:1913464 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 66214 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable R-SMAD binding activity; protein kinase activator activity; and protein kinase binding activity. Involved in fibroblast activation. Predicted to be located in centrosome; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; hindlimb interdigital region mesenchyme; liver; and male reproductive gland or organ. Orthologous to human RGCC (regulator of cell cycle). PHENOTYPE: Mice homozygous for a null allele exhibit partial prenatal lethality, abnormal vitelline vasculature morphology, and fetal growth restriction due to impaired placental angiogenesis. [provided by MGI curators] |