Primary Identifier | MGI:1277991 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 13134 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in regulation of nuclear cell cycle DNA replication. Acts upstream of or within several processes, including negative regulation of cell population proliferation; suckling behavior; and type B pancreatic cell proliferation. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; limb; and sensory organ. Orthologous to human DACH1 (dachshund family transcription factor 1). PHENOTYPE: In spite of normal gross morphology, mice homozygous for targeted mutations that inactivate this gene die within 1 day of birth. [provided by MGI curators] |